I’ve been taking Wellbutrin xr for over 20 yrs. i maybe went off of it 2-3 times only temporarily. Most people experiencing a bout of depression take the drug until the depression is lifted. Wellbutrin (Bupropion) is an antidepressant medication used for treating depression and seasonal affective disorder (SAD). How to Stop Taking Wellbutrin. Wellbutrin, or bupropion, is classified as an antidepressant and is usually used to treat depression—though, the drug is also used as a smoking cessation aid under the name Zyban. Since Wellbutrin affects b. DESCRIPTION. WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. How well does Cymbalta & wellbutrin work together, is it safe? Asked 23 Apr 2011 by want to be happy again Updated 4 September 2018 Topics cymbalta, wellbutrin, depression Wellbutrin (bupropion) is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. Wellbutrin may also be used for purposes not listed in this medication guide. Wellbutrin and Alcohol are both central nervous system-active (CNS-active) compounds and combining them can possibly lead to unwanted effects. I am trying Wellbutrin, and in 3 days, I had a terrible taste in my mouth. It has been over 8 weeks now, and it has not subsided. What other similar drugs are there to try??? Wellbutrin may affect the sex drive (also known as libido). In previous clinical studies documenting the side effects of Wellbutrin, a decreased sex drive occurred in up to 3.1 percent of people taking Wellbutrin. Although weight gain is a potential side effect of Wellbutrin, the medicine is more likely to cause weight loss. If you are taking Wellbutrin and weight gain does become a problem, be sure to talk with your healthcare provider.